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@taylercatherine

Today’s Toxicology Tuesday (or Wednesday, since this is late) is a two-part post on digoxin: today we are exploring its toxic effects, & Friday we will look at its therapeutic effects! . Digoxin is a cardiac glycoside that is derived from the foxglove plant. It has a narrow therapeutic index, meaning there is only a small margin between its therapeutic dose & its toxic dose, hence the somewhat common occurrence of poisoning. Digoxin toxicity can also occur after long-term use. Individuals with elevated calcium or low potassium may be at greater risk of toxicity. . The primary mechanism of digoxin is by blocking Na+/K+ATPase (sodium potassium adenosine triphosphatase), a ubiquitous enzyme that is vital to a number of physiological processes. Digoxin preferentially blocks this in cardiac muscle over other cell types, leading to increased heart contractility. . Symptoms of acute digoxin poisoning include hyperkalaemia, vomiting, vertigo & arrhythmia. As well as arrhythmia, digoxin may also cause tachycardia & a sinoatrial or AV block. Chronic poisoning usually has more ambiguous symptoms, such as general malaise & fatigue, in addition to visual disturbances (especially seeing yellow). . After toxicity occurs, the primary concern is with life-threatening cardiac effects & hyperkalaemia, & to stabilise the patient. Digoxin-specific antibody is administered as an antidote, & works by binding to the drug, leaving it unable to exert its effect. Activated charcoal may also be administered to remove excess digoxin from the digestive system. . Digoxin has been used historically as a poison, but perhaps the most well known case in recent times is that of Charles Cullen, an American serial killer (and former nurse) who killed 40 patients with overdoses of digoxin, & was sentenced to 18 consecutive life sentences without parole. . . #science #stem #phdlife #lablife #pharmacology #biochemistry #biology #phd #scientist #toxicology #womeninstem #scicomm #sciencecommunication #academia #discoverunder10k #womeninscience #scientistsofinstagram #thescicommunity #toxicologytuesday #pharmacologyfriday #drugs #poison #digoxin #foxglove

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@phoenixnull

Acer "Garnet" When picking it out I knew this was the one that would make me happy to be in my ramshakle garden (backyard) I have restored & decorated this house for the past 7 years, and still tools spill out into my hall & things are forever "to-do" and I look out my back windows & smile at this sight. The garden (backyard) was always last on the list and maybe, maybe i'll never get around to doing it up, but what survives makes me happy to be here & an "ocassional gardener" #nofilters #acer #garnet #plants #pots #yard #grasses #pinapplelilly #cottoneaster #geranium #strawberries #perriwinkle #foxglove

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@foxelza

У каждого свои тараканы в голове. Мои - это лисы. И это только начало. @foxelza #fox #foxes #foxy #dog #dogsofinstagram #love #foxi #foxeer #foxhound #foxglove #foxx #foxs #foxpaulistinha #fox5 #foxie #fox40 #foxtrot #foxborough #foxhole #foxing #foxtel #cute #instagood #animals #foxesofinstagram #fpv #art #nature #pet #repost at Ukraine

@sarahfarnsworthfieldsports

A lone foxglove in flower. Spotted whilst in the forest in Northumberland yesterday #foxglove #digitalispurpurea

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@annerkant_

Penstemon & Foxglove 🍃🦉 #penstemon #foxglove

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@suecollinsart

Foxglove Meadow is now finished. 😅 Now to sort out packaging and packing up to get ready for the Horsham Contemporary Art Fair this weekend 😜😜😂@horshamartistsopenstudios

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@by.raaya

Foxgloves, A1, graphite on Fabriano. On to the next 🥀

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@mosukitilli

Foxgloves (Digitalis). Self-seeded & neglected but ignored no more. Pick your poison #foxglove #digitalis #poison #bloom #beware

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@nanofevrier

Day 15 - Foxglove Who else imagines a fox with gloves in the snow ?🐺❄️ . Fairies & foxes vs. hunters. I'm joining the gang. . . . #foxglove #prettyflowers #plantmagic #drawingoftheday #inkonpaper #inktober2018 #inktober #foxes #faeries #magick #poisonousplants #toxic #fairybells #nanofevrier

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@daily_photography_18

Slightly better version of the other one 😊☀️ • • • #foxglove #flowers #beautiful #photography #colourful #pink #magenta #purple

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@alice.muelsen

Oh - ein Blümchen.🌺💕🐾 --- ☠️Aber Vorsicht! ☠️ ☠️Hochgiftig! ☠️Alle Pflanzenteile! Es ist die weiße Variante des Fingerhuts (kann auch Violett blühen). Allerdings ist es eine Heilpflanze, die auch schon früher als Medizin gegen Herzschwäche eingesetzt wurde.❤️️ Blütezeit ist eigentlich Juni bis August, dieser hat sich wohl wegen der lieben🌞 verspätet.🙂

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@benourishedpdx

Repost from @mollyccostello using @RepostRegramApp - "No one can stop us from imagining another kind of future, one which departs from the terrible cataclysm of violent conflict, of hateful divisions, poverty, and suffering. Let us begin to imagine the worlds we would like to inhabit, the long lives we will share, and the many futures in our hands."~Susan Griffin Piece for my HOMOLUMINOUS calendar. Online inventory is running low! Get yours today! . . . . . . #imagine #future #imagination #wuote #susangriffin #fire #campfire #visions #moon #community #homoluminous #homoluminouscalendar #cutpaper #illustration #paperart #stars #connected #art #collage #foxglove

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@undertheneedlemission

#hummingbird and #foxglove #flowers tattoo on the #calf

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@mollyccostello

"No one can stop us from imagining another kind of future, one which departs from the terrible cataclysm of violent conflict, of hateful divisions, poverty, and suffering. Let us begin to imagine the worlds we would like to inhabit, the long lives we will share, and the many futures in our hands."~Susan Griffin Piece for my HOMOLUMINOUS calendar. Online inventory is running low! Get yours today! . . . . . . #imagine #future #imagination #wuote #susangriffin #fire #campfire #visions #moon #community #homoluminous #homoluminouscalendar #cutpaper #illustration #paperart #stars #connected #art #collage #foxglove

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@sweet_lavender1

Blooms in fall?! I’ll take them even though it’s a chilly 4*C this morning!! Swipe for some more 🍂🌸🍂 #itsacoldone #clematisnellymoser #rosesinfall #foxglove

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@louiseselbybridal

How gorgeous does Cordelia look getting ready in simple sleeveless Foxglove ... #foxglove #highsummer #heatwave #heatwavebride #bespoke #weddingdress #sleevelessdress #louiseselbykew #louiseselbybride

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@bethduck80

Feels like spring!!! Foxglove picked by Harvey 💐 #lilaclustrejn #jetlinejn #cooloffjn #jamberry #mglobal #springflowers #foxglove #eurekaplants

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@franstanfishgo

These four plants were all planted at the same time, but four different sizes. #foxglove #ourgarden

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@kiriska

#inktober 15: Digitalis purpurea (foxglove, common foxglove). Poisonous: entire plant. Symptoms: nausea, vomiting, drooling, slow heart rate, tremors, seizures, death. #inktober2018 #inktoberday15 #flowers #foxglove #flowerdrawing #copicmarker #fountainpendrawing #fountainpenink #flowerart

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@folkishness

After spending an hour learning this song, I find out the recorded version is 170+ beats per minute 😨 challenge acceted...? 😂

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